{"id":1437,"date":"2024-08-19T14:11:07","date_gmt":"2024-08-19T13:11:07","guid":{"rendered":"https:\/\/heliusstudy.nl\/?post_type=publicatie&#038;p=1437"},"modified":"2024-08-19T14:11:07","modified_gmt":"2024-08-19T13:11:07","slug":"gut-microbiota-of-adults-with-asthma-is-broadly-similar-to-non-asthmatics-in-a-large-population-with-varied-ethnic-origins","status":"publish","type":"publicatie","link":"https:\/\/heliusstudy.nl\/tr\/publicatie\/gut-microbiota-of-adults-with-asthma-is-broadly-similar-to-non-asthmatics-in-a-large-population-with-varied-ethnic-origins\/","title":{"rendered":"Gut microbiota of adults with asthma is broadly similar to non-asthmatics in a large population with varied ethnic origins"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Bacterial gut communities might predispose children to develop asthma. Yet, little is known about the role of these micro-organisms in adult asthmatics. We aimed to profile the relationship between fecal microbiota and asthma in a large-scale, ethnically diverse, observational cohort of adults. Fecal microbiota composition of 1632 adults (172 asthmatics and 1460 non-asthmatics) was analyzed using 16S ribosomal RNA gene sequencing. Using extremely randomized trees machine learning models, we assessed the discriminatory ability of gut bacterial features to identify asthmatics from non-asthmatics. Asthma contributed 0.019% to interindividual dissimilarities in intestinal microbiota composition, which was not significant (<em>P<\/em>\u00a0= .97). Asthmatics could not be distinguished from non-asthmatics based on individual microbiota composition by an extremely randomized trees classifier model (area under the receiver operating characteristic curve = 0.54). In conclusion, there were no prominent differences in fecal microbiota composition in adult asthmatics when compared to non-asthmatics in an urban, large-sized and ethnically diverse cohort.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bacterial gut communities might predispose children to develop asthma. Yet, little is known about the role of these micro-organisms in adult asthmatics. We aimed to profile the relationship between fecal microbiota and asthma in a large-scale, ethnically diverse, observational cohort of adults. Fecal microbiota composition of 1632 adults (172 asthmatics and 1460 non-asthmatics) was analyzed [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":true},"publications_year":[24],"thema":[45],"class_list":["post-1437","publicatie","type-publicatie","status-publish","hentry","publications_year-24","thema-other"],"acf":[],"_links":{"self":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/publicatie\/1437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/publicatie"}],"about":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/types\/publicatie"}],"wp:attachment":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/media?parent=1437"}],"wp:term":[{"taxonomy":"publications_year","embeddable":true,"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/publications_year?post=1437"},{"taxonomy":"thema","embeddable":true,"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/thema?post=1437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}