{"id":1481,"date":"2024-08-19T15:26:36","date_gmt":"2024-08-19T14:26:36","guid":{"rendered":"https:\/\/heliusstudy.nl\/?post_type=publicatie&#038;p=1481"},"modified":"2024-08-19T15:29:51","modified_gmt":"2024-08-19T14:29:51","slug":"lifetime-prevalence-and-correlates-of-syncope-in-five-ancestry-groups-the-helius-study","status":"publish","type":"publicatie","link":"https:\/\/heliusstudy.nl\/tr\/publicatie\/lifetime-prevalence-and-correlates-of-syncope-in-five-ancestry-groups-the-helius-study\/","title":{"rendered":"Lifetime prevalence and correlates of syncope in five ancestry groups. The HELIUS study"},"content":{"rendered":"\n<p><strong>Aim:&nbsp;<\/strong>To explore the lifetime prevalence and correlates of syncope in the general population.<\/p>\n\n\n\n<p><strong>Methods:&nbsp;<\/strong>Through stratified random sampling, we included 14,937 White-European, Asian, Turkish, Moroccan, and West-African ancestry adults (18-70 y) in the cross-sectional Healthy Life in an Urban Setting (HELIUS) population study. We assessed syncope history by ancestry, and the potential correlates body mass index (BMI), systolic\/diastolic blood pressure (SBP\/DBP), resting plasma activity of creatine kinase (CK), the ATP-generating enzyme that facilitates cardiovascular contractility and sodium retention, and in a subgroup, supine cardiac contractility (dP\/dt), cardiac output (CO) and systemic vascular resistance (SVR).<\/p>\n\n\n\n<p><strong>Results:&nbsp;<\/strong>Mean age of the participants (39% men) was 43.3 y (SD12.9). Lifetime prevalence of syncope in women\/men was respectively (%), White-European 42\/24; Asian 34\/19; Moroccan 32\/16; Turkish 30\/17; and West-African 20\/14. Mean age at first syncope was 24 y (SD13). Participants with syncope history had lower SBP, DBP, BMI, CK, and modestly lower dP\/dt and CO, but not SVR. In multivariable regression analysis, male sex (OR 0.52 [0.48 to 0.57]), West-African ancestry (0.59 [0.54 to 0.65]), and CK (0.56 [0.46 to 0.69]\/log CK increase) were negatively associated with syncope.<\/p>\n\n\n\n<p><strong>Conclusion:&nbsp;<\/strong>This study indicates that West-African ancestry, male sex, and high activity of the pressor enzyme CK are associated with lower syncope prevalence. These findings may inform further studies on the hemodynamics of syncope.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aim:&nbsp;To explore the lifetime prevalence and correlates of syncope in the general population. Methods:&nbsp;Through stratified random sampling, we included 14,937 White-European, Asian, Turkish, Moroccan, and West-African ancestry adults (18-70 y) in the cross-sectional Healthy Life in an Urban Setting (HELIUS) population study. We assessed syncope history by ancestry, and the potential correlates body mass index [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":true},"publications_year":[23],"thema":[42],"class_list":["post-1481","publicatie","type-publicatie","status-publish","hentry","publications_year-23","thema-cardiovascular-disease"],"acf":[],"_links":{"self":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/publicatie\/1481","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/publicatie"}],"about":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/types\/publicatie"}],"wp:attachment":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/media?parent=1481"}],"wp:term":[{"taxonomy":"publications_year","embeddable":true,"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/publications_year?post=1481"},{"taxonomy":"thema","embeddable":true,"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/thema?post=1481"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}