{"id":2637,"date":"2025-03-25T16:37:53","date_gmt":"2025-03-25T15:37:53","guid":{"rendered":"https:\/\/heliusstudy.nl\/?post_type=publicatie&#038;p=2637"},"modified":"2025-03-25T16:37:55","modified_gmt":"2025-03-25T15:37:55","slug":"the-association-of-overweight-obesity-and-long-term-obesity-with-sars-cov-2-infection-a-meta-analysis-of-9-population-based-cohorts-from-the-netherlands-cohorts-consortium","status":"publish","type":"publicatie","link":"https:\/\/heliusstudy.nl\/tr\/publicatie\/the-association-of-overweight-obesity-and-long-term-obesity-with-sars-cov-2-infection-a-meta-analysis-of-9-population-based-cohorts-from-the-netherlands-cohorts-consortium\/","title":{"rendered":"The association of overweight, obesity, and long-term obesity with SARS-CoV-2 infection: a meta-analysis of 9 population-based cohorts from the Netherlands Cohorts Consortium"},"content":{"rendered":"\n<p><strong>Background:<\/strong> Obesity may affect an individual&#8217;s immune response and subsequent risk of infection, such as a SARS-CoV-2 infection. It is less clear whether overweight and long-term obesity also constitute risk factors. We investigated the association between the degree and duration of overweight and obesity and SARS-CoV-2 infection.<\/p>\n\n\n\n<p><strong>Methods: <\/strong>We analyzed data from nine prospective population-based cohorts of the Netherlands Cohorts Consortium, with a total of 99,570 participants, following a standardized procedure. Body mass index (BMI) and waist circumference (WC) were assessed two times before the pandemic, with approximately 5 years between measurements. SARS-CoV-2 infection was defined by self-report as a positive PCR or rapid-antigen test or as COVID-19 ascertained by a physician between March 2020 and January 2023. For three cohorts, information on SARS-CoV-2 infection by serology was available. Results were pooled using random-effects meta-analyses and adjusted for age, sex, educational level, and number of SARS-CoV-2 infection measurements.<\/p>\n\n\n\n<p><strong>Results: <\/strong>Individuals with overweight (25 \u2264 BMI &lt; 30 kg\/m2) (odds ratio (OR) = 1.08, 95%-confidence interval (CI) 1.04-1.13) or obesity (BMI \u2265 30 kg\/m2) (OR = 1.43, 95%-CI 1.18-1.75) were more likely to report SARS-CoV-2 infection than individuals with a healthy body weight. We observed comparable ORs for abdominal overweight (men: 94 cm\u2264WC &lt; 102 cm, women: 80 cm\u2264WC &lt; 88 cm) (OR = 1.09, 95%-CI 1.04-1.14, I2 = 0%) and abdominal obesity (men: WC \u2265 102 cm, women: WC \u2265 88 cm) (OR = 1.24, 95%-CI 0.999-1.55, I2 = 57%). Individuals with obesity long before the pandemic, but with a healthy body weight or overweight just before the pandemic, were not at increased risk.<\/p>\n\n\n\n<p><strong>Conclusion:<\/strong> Overweight and obesity were associated with increased risk of SARS-CoV-2 infection with stronger associations for obesity. Individuals with a healthier weight prior to the pandemic but previous obesity did not have an increased risk of SARS-CoV-2, suggesting that weight loss in those with obesity reduces infection risk. These results underline the importance of obesity prevention and weight management for public health.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background: Obesity may affect an individual&#8217;s immune response and subsequent risk of infection, such as a SARS-CoV-2 infection. It is less clear whether overweight and long-term obesity also constitute risk factors. We investigated the association between the degree and duration of overweight and obesity and SARS-CoV-2 infection. Methods: We analyzed data from nine prospective population-based [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":true},"publications_year":[21],"thema":[44],"class_list":["post-2637","publicatie","type-publicatie","status-publish","hentry","publications_year-21","thema-infectious-disease"],"acf":[],"_links":{"self":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/publicatie\/2637","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/publicatie"}],"about":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/types\/publicatie"}],"wp:attachment":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/media?parent=2637"}],"wp:term":[{"taxonomy":"publications_year","embeddable":true,"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/publications_year?post=2637"},{"taxonomy":"thema","embeddable":true,"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/thema?post=2637"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}