{"id":2642,"date":"2025-03-25T16:25:08","date_gmt":"2025-03-25T15:25:08","guid":{"rendered":"https:\/\/heliusstudy.nl\/?post_type=publicatie&#038;p=2642"},"modified":"2025-03-25T16:25:09","modified_gmt":"2025-03-25T15:25:09","slug":"effects-of-antihypertensives-with-and-without-il-6-lowering-properties-on-long-term-blood-pressure-control-the-prospective-helius-cohort","status":"publish","type":"publicatie","link":"https:\/\/heliusstudy.nl\/tr\/publicatie\/effects-of-antihypertensives-with-and-without-il-6-lowering-properties-on-long-term-blood-pressure-control-the-prospective-helius-cohort\/","title":{"rendered":"Effects of antihypertensives with and without IL-6 lowering properties on long-term blood pressure control: The prospective HELIUS cohort"},"content":{"rendered":"\n<p><strong>Background:&nbsp;<\/strong>Chronic inflammation is a well-recognized contributor to hypertension pathogenesis. However, the role of targeting inflammation in hypertension treatment, particularly through modulation of inflammatory markers like interleukin-6 (IL-6), remains less understood. We investigated the effects of antihypertensive medications with and without IL-6-lowering properties on long-term blood pressure (BP) control in a multi-ethnic cohort in the Netherlands.<\/p>\n\n\n\n<p><strong>Methods:&nbsp;<\/strong>Participants from HELIUS cohort receiving hypertension treatment were followed over six years. BP control at follow-up was determined using WHO criteria. Due to unavailability of IL-6 data, a literature review was conducted to classify antihypertensives based on their IL-6-lowering properties &#8211; a proxy approach. Logistic regression models were used to assess associations between the IL-6-lowering potential of antihypertensives and BP control, both within and between antihypertensive classes. Effect modification by ethnicity was explored.<\/p>\n\n\n\n<p><strong>Results:&nbsp;<\/strong>A total of 1510 participants were included (mean age 57 years, 62 % women). Within the calcium channel blocker (CCB) class, medications with IL-6-lowering properties (amlodipine and barnidipine) were associated with superior BP control (aOR 1.41, 95 % confidence interval 1.05-1.90) compared to other CCBs (lercanidipine, nifedipine, verapamil, clevidipine, diltiazem). No significant associations were observed within angiotensin receptor blockers (ARBs) or angiotensin-converting enzyme inhibitors (ACEIs), between different antihypertensive drug classes, nor across ethnic groups.<\/p>\n\n\n\n<p><strong>Conclusion:&nbsp;<\/strong>Amlodipine and barnidipine were associated with better BP control compared to other CCBs. Our findings provide an important starting point for understanding the role of IL-6 in hypertension management. Further studies are warranted to confirm these observations by directly measuring IL-6 levels and investigating underlying mechanisms.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background:&nbsp;Chronic inflammation is a well-recognized contributor to hypertension pathogenesis. However, the role of targeting inflammation in hypertension treatment, particularly through modulation of inflammatory markers like interleukin-6 (IL-6), remains less understood. We investigated the effects of antihypertensive medications with and without IL-6-lowering properties on long-term blood pressure (BP) control in a multi-ethnic cohort in the Netherlands. [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":true},"publications_year":[21],"thema":[42],"class_list":["post-2642","publicatie","type-publicatie","status-publish","hentry","publications_year-21","thema-cardiovascular-disease"],"acf":[],"_links":{"self":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/publicatie\/2642","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/publicatie"}],"about":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/types\/publicatie"}],"wp:attachment":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/media?parent=2642"}],"wp:term":[{"taxonomy":"publications_year","embeddable":true,"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/publications_year?post=2642"},{"taxonomy":"thema","embeddable":true,"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/thema?post=2642"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}