{"id":2646,"date":"2025-03-25T16:21:21","date_gmt":"2025-03-25T15:21:21","guid":{"rendered":"https:\/\/heliusstudy.nl\/?post_type=publicatie&#038;p=2646"},"modified":"2025-03-25T16:21:22","modified_gmt":"2025-03-25T15:21:22","slug":"autonomic-cardiac-control-independently-predicts-incident-hypertension-and-systolic-blood-pressure-in-a-multi-ethnic-population-the-helius-study","status":"publish","type":"publicatie","link":"https:\/\/heliusstudy.nl\/tr\/publicatie\/autonomic-cardiac-control-independently-predicts-incident-hypertension-and-systolic-blood-pressure-in-a-multi-ethnic-population-the-helius-study\/","title":{"rendered":"Autonomic cardiac control independently predicts incident hypertension and systolic blood pressure in a multi-ethnic population: The HELIUS study"},"content":{"rendered":"\n<p><strong>Aims:&nbsp;<\/strong>Cross-correlation baroreflex sensitivity (xBRS) and heart rate variability (HRV) are measures of autonomic cardiac control and are associated with hypertension. However, their value in predicting new-onset hypertension and changes in systolic blood pressure (SBP) remains elusive.<\/p>\n\n\n\n<p><strong>Methods:&nbsp;<\/strong>We used longitudinal data of participants with- and without a history of cardiovascular disease from the HEalthy Life In an Urban Setting (HELIUS) study. A non-invasive continuous finger blood pressure measurement at baseline was used to calculate xBRS and HRV. In normotensives at baseline we calculated the odds ratio (OR) of developing hypertension at follow-up. In the full cohort we assessed the change in SBP between baseline and follow-up using linear regression. Subgroup analyses were performed in the younger (&lt;50 years) and older (\u226550 years) participants.<\/p>\n\n\n\n<p><strong>Results:&nbsp;<\/strong>Median follow-up was 6.6 years (IQR 5.8-7.4). A 50% lower xBRS at baseline was independently associated with a 1.31 higher OR (95% CI 1.09-1.57) of developing hypertension at follow-up. No significant associations between the standard deviation normal-to-normal interval (SDNN) or the root mean square of differences in successive normal-to-normal interval (RMSDD), and new-onset hypertension were found. Compared to the lowest tertile, an xBRS in the highest tertile was associated with a 3.61 mmHg (95%CI 2.50-4.71) higher increase in SBP over time, whereas this was 1.11 mmHg (95%CI 0.12-2.09) and 1.76 mmHg (95%CI 0.73-2.79) for SDNN and RMSDD.<\/p>\n\n\n\n<p><strong>Conclusion:&nbsp;<\/strong>In the general population, a lower xBRS is associated with increased odds of developing hypertension, and a steeper increase in SBP over time.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aims:&nbsp;Cross-correlation baroreflex sensitivity (xBRS) and heart rate variability (HRV) are measures of autonomic cardiac control and are associated with hypertension. However, their value in predicting new-onset hypertension and changes in systolic blood pressure (SBP) remains elusive. Methods:&nbsp;We used longitudinal data of participants with- and without a history of cardiovascular disease from the HEalthy Life In [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":true},"publications_year":[147],"thema":[42],"class_list":["post-2646","publicatie","type-publicatie","status-publish","hentry","publications_year-147","thema-cardiovascular-disease"],"acf":[],"_links":{"self":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/publicatie\/2646","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/publicatie"}],"about":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/types\/publicatie"}],"wp:attachment":[{"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/media?parent=2646"}],"wp:term":[{"taxonomy":"publications_year","embeddable":true,"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/publications_year?post=2646"},{"taxonomy":"thema","embeddable":true,"href":"https:\/\/heliusstudy.nl\/tr\/wp-json\/wp\/v2\/thema?post=2646"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}