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Researchers

24,780 baseline participants

11,035 follow-up participants

21,000 baseline biological samples

Publications

Since 2011, more than 200 scientific articles based on the HELIUS data have been published. Below you can find, filter and read them.

Filters

Theme

Year

Estimating Additive Interaction in Two-Stage Individual Participant Data Meta-Analysis

Year: 2024
Authors: Basten M, van Tuijl LA, Pan KY, Hoogendoorn AW, Lamers F, Ranchor AV, Dekker J, Frank P, Galenkamp H, Knol MJ, Noisel N, Payette Y, Sund ER, Zwinderman AH, Portengen L, Geerlings MI

Effects of antihypertensives with and without IL-6 lowering properties on long-term blood pressure control: The prospective HELIUS cohort

Year: 2024
Authors: Batuo H, van der Linden E, Galenkamp H, Moll van Charante E, van der Born BJ, Chilunga FP

Machine learning analysis of sex and menopausal differences in the gut microbiome in the HELIUS study

Year: 2024
Authors: Vriend EMC, Galenkamp H, Herrema H, Nieuwdorp M, van den Born BJH, Verhaar BJH

Mid-life association between cardiovascular risk factors and cerebral blood flow in a multi-ethnic population

Year: 2024
Authors: Vriend EMC, Dijsselhof MBJ, Bouwmeester TA, Franco OH, Galenkamp H, Collard D, Nederveen AJ, van den Born BJH, Mutsaerts HJMM

Validation of the enhanced liver fibrosis (ELF)-test in heparinized and EDTA plasma for use in reflex testing algorithms for metabolic dysfunction-associated steatotic liver disease (MASLD)

Year: 2024
Authors: van Son KC, van Dijk AM, Driessen S, Mak AL, Witjes JJ, Houttu VAT, Zwirs D, Nieuwdorp M, van den Born BJH, Fischer JC, Tushuizen ME, Drenth JPH, Hamer HM, Beuers UHW, Verheij J, Holleboom AG

The Association between Post-Traumatic Stress Disorder and Problematic Alcohol and Cannabis Use in a Multi-Ethnic Cohort in The Netherlands: The HELIUS Study

Year: 2024
Authors: Kühner C, Will JP, Lortye SA, Galenkamp H, Lok A, van Zuiden M, Arntz AR, Thomaes K, Goudriaan AE, de Waal MM

The association of overweight, obesity, and long-term obesity with SARS-CoV-2 infection: a meta-analysis of 9 population-based cohorts from the Netherlands Cohorts Consortium

Year: 2024
Authors: Loef B, Boer JMA, Beekman M, Campman SL, Hoogendijk EO, Huider F, Pagen DME, Splinter MJ, van der Velde JHPM, Boomsma DI, Dagnelie PC, van Dongen J, de Geus EJC, Huisman M, Arfan Ikram M, Koster A, Licher S, Mierau JO, de Mutsert R, Picavet HSJ, Rosendaal FR, Schram MT, Slagboom PE, van der Spoel E, Stronks K, Verschuren WMM, van den Berg SW; Lifelines Corona Research initiative

Differences in SARS-CoV-2 antibody prevalence at the end of the pre-vaccination period between age groups: A cross-sectional analysis of the multi-ethnic population-based HELIUS study

Year: 2024
Authors: Bolijn R, Spijkerman AMW, Galenkamp H, Blokstra A, Coyer L, Boyd A, Prins M, Stronks K

ECG Changes during Adult Life in Fabry Disease: Results from a Large Longitudinal Cohort Study

Year: 2023
Authors: El Sayed M, Postema PG, Datema M, van Dussen L, Kors JA, Ter Haar CC, Bleijendaal H, Galenkamp H, van den Born BH, Hollak CEM, Langeveld M

Perceived ethnic discrimination, suicidal ideation and mastery in a multi-ethnic cohort: the HELIUS study

Year: 2023
Authors: Willemen FEM, Heuschen CBBCM, Zantvoord JB, Galenkamp H, de Wit MAS, Zwinderman AH, Denys DAJP, Bockting CLH, Stronks K, Lok A

About HELIUS

The HELIUS study is a prospective cohort study on health and health care among an urban multi-ethnic population.

The aim of the HELIUS study is to gain insight in the biological, psychological and social causes of the unequal burden of disease across ethnic groups, and ultimately enable the improvement of health care and prevention strategies. The study is being carried out in Amsterdam, the Netherlands, and is an initiative of Amsterdam UMC and the Public Health Service of Amsterdam (GGD Amsterdam).

The HELIUS study focuses on three primary research areas:

  • Cardiovascular diseases (including diabetes)
  • Mental disorders
  • Infectious diseases

Baseline data collection took place in 2011-2015. Nearly 25.000 participants of Turkish, Moroccan, South-Asian Surinamese, African Surinamese, Ghanaian and Dutch origin were included in the study. Data were collected through a questionnaire/interview and a physical examination. Biological samples were obtained during study visits. In 2019 – 2022, all HELIUS participants were invited for follow-up measurements. Again, a physical examination was performed, including the collection of biological samples.

For more information on the study design and data collection, we refer to the following papers:

Collaboration

HELIUS has an open policy in regard to collaboration with research groups.

Researchers from various departments of Amsterdam UMC and the GGD Amsterdam collaborate in the HELIUS study. In addition, we are open to proposals of collaboration with external research groups.

  • Before access to data is provided, all researchers should carefully read and must adhere to the HELIUS Collaboration Policy.
  • In brief, a research proposal or publication proposal must be developed following the proposal formats, which can be found in the Collaboration Policy.
  • All proposals should then be submitted to the HELIUS Scientific Coordinator (heliuscoordinator@amsterdamumc.nl). The proposals are discussed in the HELIUS Executive Board regarding their study aims, overlap with ongoing studies, logistic consequences and financial contributions.
  • After approval of the proposal by the HELIUS Executive Board, the collaborative research project is embedded in one of the three research areas supervised by the specific HELIUS Theme Leader.

Linkages

Several linkages have been established with national or regional registries in the Netherlands, to enrich the data:

Consortia

We collaborate with multiple national and international consortia.

FAQ researchers

Who can collaborate?

Researchers affiliated with a Dutch or international research institute may request data or samples to conduct a study that fits within the general aims of HELIUS.

Proposals regarding scientific collaboration should be submitted to the Scientific Coordinator, preferably after consulting the relevant Theme Leader. The proposals will then be considered by the HELIUS Executive Board, on the basis of: 1. compatibility with the general objectives of the HELIUS study, 2. the quality of the research proposal, 3. possible overlap with other cohort studies, 4. the use of biological material, 5. logistical feasibility and 6. the (financial) contribution to be made.

Data collection consists of questionnaires, physical examination and collection of biomaterial. For an overview, see:

Yes, for access to data and biomaterial we follow the procedures as set out in the HELIUS Collaboration Policy, which you can download here.

Onze partners

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