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Researchers

24,780 baseline participants

11,035 follow-up participants

21,000 baseline biological samples

Publications

Since 2011, more than 200 scientific articles based on the HELIUS data have been published. Below you can find, filter and read them.

Filters

Theme

Year

Sex differences in CKD risk factors across ethnic groups 

Year: 2024
Authors: Vosters TG, Kingma FM, Stel VS, van den Born BH, Huisman BJMV, van Ittersum FJ, Jager KJ, Vogt L, van Valkengoed IGM

Estimating the contribution of overweight and obesity to ethnic inequalities in cardio-metabolic diseases in the Netherlands: a simulation study

Year: 2024
Authors: Nusselder WJ, Long D, Waterlander WE, Stronks K, Boshuizen HC

Genetic variance in heparen sulfation is sssociated with salt-sensitivity: a gene-environment analysis

Year: 2024
Authors: Oppelaar J, Ferwerda B, Romman M, Sahebdin G, Zwinderman A, Galenkamp H, Boekholdt M, Van Den Born BJ, Engberink RO, Vogt L

Differences in gut microbiota between Dutch and South-Asian Surinamese: potential implications for type 2 diabetes mellitus

Year: 2024
Authors: Nayman EI, Schwartz BA, Polmann M, Gumabong AC, Nieuwdorp M, Cickovski T, Mathee K

Comparative Analysis of Taxonomic and Functional Gut Microbiota Profiles in Relation to Seroconversion of Thyroid Peroxidase Antibodies in Euthyroid Participants

Year: 2024
Authors: Fenneman AC, Boulund U, Collard D, Galenkamp H, Zwinderman AH, van den Born BH, van der Spek AH, Fliers E, Rampanelli E, Blaser MJ, Nieuwdorp M

The association of obesogenic environments with weight status, blood pressure, and blood lipids: A cross-sectional pooled analysis across five cohorts

Year: 2024
Authors: Meijer P, Lam TM, Vaartjes I, Moll van Charante E, Galenkamp H, Koster A, van den Hurk K, den Braver NR, Blom MT, de Jong T, Grobbee DE, Beulens JW, Lakerveld J; GECCO consortium

Exposome-Wide Association Study of Body Mass Index Using a Novel Meta-Analytical Approach for Random Forest Models

Year: 2024
Authors: Ohanyan H, van de Wiel M, Portengen L, Wagtendonk A, den Braver NR, de Jong TR, Verschuren M, van den Hurk K, Stronks K, Moll van Charante E, van Schoor NM, Stehouwer CDA, Wesselius A, Koster A, Ten Have M, Penninx BWJH, van Wier MF, Motoc I, Oldehinkel AJ, Willemsen G, Boomsma DI, Beenackers MA, Huss A, van Boxtel M, Hoek G, Beulens JWJ, Vermeulen R, Lakerveld J

Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis

Year: 2024
Authors: Basten M, Pan KY, van Tuijl LA, de Graeff A, Dekker J, Hoogendoorn AW, Lamers F, Ranchor AV, Vermeulen R, Portengen L, Voogd AC, Abell J, Awadalla P, Beekman ATF, Bjerkeset O, Boyd A, Cui Y, Frank P, Galenkamp H, Garssen B, Hellingman S, Huisman M, Huss A, Keats MR, Kok AAL, Krokstad S, van Leeuwen FE, Luik AI, Noisel N, Payette Y, Penninx BWJH, Rissanen I, Roest AM, Rosmalen JGM, Ruiter R, Schoevers RA, Soave D, Spaan M, Steptoe A, Stronks K, Sund ER, Sweeney E, Twait EL, Teyhan A, Verschuren WMM, van der Willik KD, Geerlings MI

Phytate metabolism is mediated by microbial cross-feeding in the gut microbiota

Year: 2024
Authors: De Vos WM, Nguyen Trung M, Davids M, Liu G, Rios-Morales M, Jessen H, Fiedler D, Nieuwdorp M, Bui TPN

Adding ethnicity to cardiovascular risk prediction: External validation and model updating of SCORE2 using data from the HELIUS population cohort

Year: 2024
Authors: van Apeldoorn JAN, Hageman SHJ, Harskamp RE, Agyemang C, van den Born BH, van Dalen JW, Galenkamp H, Hoevenaar-Blom MP, Richard E, van Valkengoed IGM, Visseren FLJ, Dorresteijn JAN, Moll van Charante EP

About HELIUS

The HELIUS study is a prospective cohort study on health and health care among an urban multi-ethnic population.

The aim of the HELIUS study is to gain insight in the biological, psychological and social causes of the unequal burden of disease across ethnic groups, and ultimately enable the improvement of health care and prevention strategies. The study is being carried out in Amsterdam, the Netherlands, and is an initiative of Amsterdam UMC and the Public Health Service of Amsterdam (GGD Amsterdam).

The HELIUS study focuses on three primary research areas:

  • Cardiovascular diseases (including diabetes)
  • Mental disorders
  • Infectious diseases

Baseline data collection took place in 2011-2015. Nearly 25.000 participants of Turkish, Moroccan, South-Asian Surinamese, African Surinamese, Ghanaian and Dutch origin were included in the study. Data were collected through a questionnaire/interview and a physical examination. Biological samples were obtained during study visits. In 2019 – 2022, all HELIUS participants were invited for follow-up measurements. Again, a physical examination was performed, including the collection of biological samples.

For more information on the study design and data collection, we refer to the following papers:

Collaboration

HELIUS has an open policy in regard to collaboration with research groups.

Researchers from various departments of Amsterdam UMC and the GGD Amsterdam collaborate in the HELIUS study. In addition, we are open to proposals of collaboration with external research groups.

  • Before access to data is provided, all researchers should carefully read and must adhere to the HELIUS Collaboration Policy.
  • In brief, a research proposal or publication proposal must be developed following the proposal formats, which can be found in the Collaboration Policy.
  • All proposals should then be submitted to the HELIUS Scientific Coordinator (heliuscoordinator@amsterdamumc.nl). The proposals are discussed in the HELIUS Executive Board regarding their study aims, overlap with ongoing studies, logistic consequences and financial contributions.
  • After approval of the proposal by the HELIUS Executive Board, the collaborative research project is embedded in one of the three research areas supervised by the specific HELIUS Theme Leader.

Linkages

Several linkages have been established with national or regional registries in the Netherlands, to enrich the data:

Consortia

We collaborate with multiple national and international consortia.

FAQ researchers

Who can collaborate?

Researchers affiliated with a Dutch or international research institute may request data or samples to conduct a study that fits within the general aims of HELIUS.

Proposals regarding scientific collaboration should be submitted to the Scientific Coordinator, preferably after consulting the relevant Theme Leader. The proposals will then be considered by the HELIUS Executive Board, on the basis of: 1. compatibility with the general objectives of the HELIUS study, 2. the quality of the research proposal, 3. possible overlap with other cohort studies, 4. the use of biological material, 5. logistical feasibility and 6. the (financial) contribution to be made.

Data collection consists of questionnaires, physical examination and collection of biomaterial. For an overview, see:

Yes, for access to data and biomaterial we follow the procedures as set out in the HELIUS Collaboration Policy, which you can download here.

Onze partners

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